Medication module
duloxetine delayed-release
Cymbalta · Delayed-release (enteric-coated) capsule
Why
Cymbalta is on the ISMP “Do Not Crush” list, and FDA labeling says do not chew or crush and do not open the capsule and sprinkle its contents on food or mix with liquids, because these actions might affect the enteric coating.
What to ask the pharmacist instead
Ask the pharmacist about Drizalma Sprinkle, a duloxetine product whose FDA label specifically allows opening and sprinkling on applesauce.
SourceISMP “Do Not Crush” list; FDA labeling: do not crush, chew, or sprinkle
Clinical review2026-06-10 · pharmacist-checked
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.