Medication module
alendronate
Fosamax · Tablet (mucous membrane irritant)
Why
Fosamax is on the ISMP “Do Not Crush” list as a mucous membrane irritant. FDA labeling warns of severe esophageal reactions and potential oropharyngeal ulceration, instructing patients not to chew or suck the tablet and to swallow it with a full glass of plain water while staying upright.
What to ask the pharmacist instead
Ask the pharmacist about the FDA-approved alendronate oral solution or other osteoporosis treatments that do not require swallowing a tablet.
SourceISMP “Do Not Crush” list (mucous membrane irritant); FDA esophagitis warning
Clinical review2026-06-10 · pharmacist-checked
Confirm with your pharmacist before changing how any medication is taken. This page never provides dosing guidance.